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Alternative name
BS 84, HSD 1, hSMP 1, SMP 1, SMP1, SPAG3, SPAG8, sperm associated antigen 8, Sperm membrane protein 1, Sperm membrane protein BS 84 antibody
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Catalog
A008146
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC,IP
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PurificationImmunogen affinity purified
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Immunogensperm associated antigen 8
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IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A008146(SPAG8 antibody) at dilution of 1:100
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Western BlotPC-3 cells were subjected to SDS PAGE followed by western blot with A008146(SPAG8 antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalPlays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252).
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Gene nameSPAG8
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Uniprot IDQ99932
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Observed M.W.56-65 kDa
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