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Alternative name
CIS3, SSI3 antibody
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Catalog
A008100
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,WB,IF,IP
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PurificationImmunogen affinity purified
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Immunogensuppressor of cytokine signaling 3
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IHCImmunohistochemistry of paraffin-embedded human heart using A008100(SOCS3 antibody) at dilution of 1:50
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Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A008100(SOCS3 antibody) at dilution of 1:500
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Recommended dilutionWB:1:200-1:2000;IP:1:200-1:2000;IHC:1:20-1:200;IF:1:10-1:100
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Product Description specificalSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
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Gene nameSOCS3
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locationcytoplasm
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Uniprot IDO14543
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Calculated M.W.25kDa,observed 30kDa
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Observed M.W.30 kDa
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