anti-SOCS1 antibody

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  • Alternative name

    SSI1, TIP3 antibody

  • Catalog
    A008099
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,IHC,IF,WB
  • PurificationImmunogen affinity purified
  • Immunogensuppressor of cytokine signaling 1
  • IHCImmunohistochemistry of paraffin-embedded human placenta tissue slide using A008099( SOCS1 Antibody) at dilution of 1:50
  • Western BlotTransfected HEK-293 cells were subjected to SDS PAGE followed by western blot with A008099( SOCS1 Antibody) at dilution of 1:1000
  • Recommended dilutionWB : 1:500-1:5000
  • Product Description specificalSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
  • Gene nameSOCS1
  • Uniprot IDO15524




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