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Alternative name
KIAA0488 antibody
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Catalog
A008090
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogensorting nexin family member 27
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IHCImmunohistochemistry of paraffin-embedded human cervical cancer tissue slide using A008090( SNX27 Antibody) at dilution of 1:50
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Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A008090(SNX27 antibody) at dilution of 1:1200
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalInvolved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
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Gene nameSNX27
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Uniprot IDQ96L92
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Observed M.W.52-60kd
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