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Alternative name
KMT3C antibody
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Catalog
A008048
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IF,IHC
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PurificationImmunogen affinity purified
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ImmunogenSET and MYND domain containing 2
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IHCImmunohistochemistry of paraffin-embedded human heart using A008048(SMYD2 antibody) at dilution of 1:100
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Western Blotmouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with A008048(SMYD2 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalProtein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
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Gene nameSMYD2
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Uniprot IDQ9NRG4
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Observed M.W.50kd
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