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Alternative name
KIAA1625 antibody
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Catalog
A008046
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenSMAD specific E3 ubiquitin protein ligase 1
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IHCImmunohistochemistry of paraffin-embedded human colon cancer tissue slide using A008046( SMURF1 Antibody) at dilution of 1:50
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Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A008046(SMURF1 antibody) at dilution of 1:800
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalE3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
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Gene nameSMURF1
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Uniprot IDQ9HCE7
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Observed M.W.83-90 kDa
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