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Alternative name
EST1B, KIAA1089 antibody
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Catalog
A008025
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenSmg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
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IHCImmunohistochemistry of paraffin-embedded human cervical cancer using A008025(SMG5 antibody) at dilution of 1:100
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A008025(SMG5 antibody) at dilution of 1:400
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalPlays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.
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Gene nameSMG5
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Uniprot IDQ9UPR3
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Observed M.W.150kd
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