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Alternative name
MADH2, MADR2，hMAD 2, hSMAD2, JV18, JV18 1, MAD homolog 2, Mad related protein 2, Mothers against DPP homolog 2, SMAD 2, SMAD family member 2, SMAD2 antibody
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Catalog
A007993
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF,IP
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PurificationImmunogen affinity purified
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ImmunogenSMAD family member 2
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IHCImmunohistochemistry of paraffin-embedded human endometrial cancer tissue slide using A007993( SMAD2 Antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A007993(SMAD2 antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:50-1:500
IF : 1:10-1:100
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Product Description specificalReceptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
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Gene nameSMAD2
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Uniprot IDQ15796
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Calculated M.W.58 kDa
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Observed M.W.58 kDa
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