anti-SIGLEC7 antibody

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  • Alternative name

    AIRM1 antibody

  • Catalog
    A007862
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,WB,IHC
  • PurificationImmunogen affinity purified
  • Immunogensialic acid binding Ig-like lectin 7
  • IHCImmunohistochemistry of paraffin-embedded human tonsillitis slide using A007862( SIGLEC7 Antibody) at dilution of 1:50
  • Western BlotU-937 cells were subjected to SDS PAGE followed by western blot with A007862(SIGLEC7 antibody) at dilution of 1:1000
  • Recommended dilutionWB : 1:500-1:5000
  • Product Description specificalPutative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
  • Gene nameSIGLEC7
  • Uniprot IDQ9Y286
  • Observed M.W.75 kDa


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