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Alternative name
MOB, SMS1, TMEM23 antibody
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Catalog
A007811
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogensphingomyelin synthase 1
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IHCImmunohistochemistry of paraffin-embedded human liver using A007811(SGMS1 antibody) at dilution of 1:50
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Western Blothuman heart tissue were subjected to SDS PAGE followed by western blot with A007811(SGMS1 antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalSphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
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Gene nameSGMS1
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Uniprot IDQ86VZ5
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Observed M.W.50 kDa
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