StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman, Mouse , Zebrafish
PurificationImmunogen affinity purified
Immunogenbeta-site APP-cleaving enzyme 1
IHCImmunohistochemistry of paraffin-embedded mouse brain tissue slide using A000781( BACE1 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A000781(BACE1 antibody) at dilution of 1:500
Recommended dilutionWB : 1:200-1:2000
Product Description specificalResponsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.