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Alternative name
SAP145 antibody
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Catalog
A007778
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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Immunogensplicing factor 3b, subunit 2, 145kDa
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IHCImmunohistochemistry of paraffin-embedded human colon cancer using A007778(SF3B2 antibody) at dilution of 1:10
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Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A007778(SF3B2 antibody) at dilution of 1:400
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalSubunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
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Gene nameSF3B2
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Uniprot IDQ13435
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Observed M.W.130-140 kDa
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