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Alternative name
KIAA1076, KMT2G, SET1B antibody
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Catalog
A007766
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IP,IHC
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PurificationImmunogen affinity purified
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ImmunogenSET domain containing 1B
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IHCImmunohistochemistry of paraffin-embedded human ovary tumor tissue slide using A007766( SETD1B Antibody) at dilution of 1:50
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Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A007766(SETD1B antibody) at dilution of 1:800
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalHistone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
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Gene nameSETD1B
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Uniprot IDQ9UPS6
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Observed M.W.250-260 kDa, 450 kDa
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