StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat
PurificationImmunogen affinity purified
ImmunogenSEC13 homolog (S. cerevisiae)
IHCImmunohistochemistry of paraffin-embedded mouse brain tissue slide using A007677( SEC13 Antibody) at dilution of 1:50
Western BlotHepG2 cells were subjected to SDS PAGE followed by western blot with A007677(SEC13 antibody) at dilution of 1:1000
Recommended dilutionWB : 1:500-1:5000
Product Description specificalFunctions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. _x000D_As a component of the GATOR subcomplex GATOR2, functions as an activator of the amino acid-sensing branch of the TORC1 pathway. Inhibits the GATOR1 subcomplex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway (PubMed:23723238). Functions downstream and is regulated by amino acid sensors like SESN2 (Probable).