-
Alternative name
AML3, CBFA1, OSF2, PEBP2A antibody
-
Catalog
A007536
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman, Rat
-
Applications Tested/SuitableELISA,WB
-
PurificationImmunogen affinity purified
-
Immunogenrunt-related transcription factor 2
-
Western BlotROS1728 cell were subjected to SDS PAGE followed by western blot with A007536 (RUNX2 Antibody) at
dilution of 1:600
-
Recommended dilutionWB: 1:200-1:2000
-
Product Description specificalTranscription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
-
Gene nameRUNX2
-
Uniprot IDQ13950
-
Observed M.W.60 kDa
-