-
Alternative name
HHR23A, HR23A, RAD23A antibody
-
Catalog
A007077
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman, Mouse ,Rat
-
Applications Tested/SuitableELISA,WB,IHC,IP
-
PurificationImmunogen affinity purified
-
ImmunogenRAD23 homolog A (S. cerevisiae)
-
IHCImmunohistochemistry of paraffin-embedded human lymphoma using A007077(RAD23A antibody) at dilution of 1:50
-
Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A007077(RAD23A antibody) at dilution of 1:500
-
Recommended dilutionWB : 1:1000-1:10000
-
Product Description specificalMultiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome._x000D_Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC._x000D_Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.
-
Gene nameRAD23A
-
Uniprot IDP54725
-
Observed M.W.55kd
-