-
Alternative name
MEL, Oncogene c mel, RAB8, RAB8A, Ras related protein Rab 8A antibody
-
Catalog
A007045
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Mouse ,Rat
-
Applications Tested/SuitableELISA,WB,IF,IP
-
PurificationImmunogen affinity purified
-
ImmunogenRAB8A, member RAS oncogene family
-
Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with 55296-1-AP(RAB8A antibody) at dilution of 1:1000
-
Recommended dilutionWB : 1:500-1:5000
IP : 1:200-1:2000
IF : 1:10-1:100
-
Product Description specificalThe small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis.
-
Gene nameRAB8A
-
Uniprot IDP61006
-
Calculated M.W.24kDa
-
Observed M.W.24 kDa
-