anti-PTPN22 antibody

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  • Alternative name

    PTPN8 antibody

  • Catalog
    A006936
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC,IP
  • PurificationImmunogen affinity purified
  • Immunogenprotein tyrosine phosphatase, non-receptor type 22 (lymphoid)
  • IHCImmunohistochemistry of paraffin-embedded human lymphoma using A006936(PTPN22 antibody) at dilution of 1:50
  • Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A006936(PTPN22 antibody) at dilution of 1:600
  • Recommended dilutionWB : 1:200-1:2000
  • Product Description specificalActs as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr- 493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro- inflammatory cytokine secretion and autophagy (PubMed:23991106).
  • Gene namePTPN22
  • Uniprot IDQ9Y2R2
  • Observed M.W.79-95 kDa


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