StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat
PurificationImmunogen affinity purified
IHCImmunohistochemistry of paraffin-embedded human gliomas tissue slide using A006926( PTN Antibody) at dilution of 1:50
Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A006926(PTN antibody) at dilution of 1:800
Recommended dilutionWB : 1:200-1:2000
Product Description specificalSecreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).