IHCImmunohistochemistry of paraffin-embedded human colon cancer using A006896(PSME3 antibody) at dilution of 1:50
Western Blothuman colon tissue were subjected to SDS PAGE followed by western blot with A006896(PSME3 antibody) at dilution of 1:500
Recommended dilutionWB : 1:200-1:2000
Product Description specificalSubunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).