anti-PSME3 antibody

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  • Alternative name

    Ki, Ki nuclear autoantigen, PA28 gamma, PA28G, PA28gamma, PSME3, REG GAMMA antibody

  • Catalog
    A006896
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC,IF,IP
  • PurificationImmunogen affinity purified
  • Immunogenproteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
  • IHCImmunohistochemistry of paraffin-embedded human colon cancer using A006896(PSME3 antibody) at dilution of 1:50
  • Western Blothuman colon tissue were subjected to SDS PAGE followed by western blot with A006896(PSME3 antibody) at dilution of 1:500
  • Recommended dilutionWB : 1:200-1:2000
  • Product Description specificalSubunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).
  • Gene namePSME3
  • Uniprot IDP61289
  • Observed M.W.30 kDa




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