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Alternative name
DKFZp781I2452, PKA C beta, PKACB, PRKACB antibody
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Catalog
A006778
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF,IP
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PurificationImmunogen affinity purified
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Immunogenprotein kinase, cAMP-dependent, catalytic, beta
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IHCImmunohistochemistry of paraffin-embedded human medulloblastoma using A006778(PRKACB antibody) at dilution of 1:50
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Western BlotHT-1080 cells were subjected to SDS PAGE followed by western blot with A006778(PRKACB antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:1000-1:10000
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Product Description specificalMediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
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Gene namePRKACB
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Uniprot IDP22694
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Observed M.W.46-55 kDa
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