anti-ATG12 antibody

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  • Alternative name

    APG12, APG12L antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman, Mouse
  • Applications Tested/SuitableELISA,WB,IHC,IP
  • PurificationImmunogen affinity purified
  • ImmunogenATG12 autophagy related 12 homolog (S. cerevisiae)
  • IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A000666(ATG12 antibody) at dilution of 1:50
  • Western Blothuman bladder tissue were subjected to SDS PAGE followed by western blot with A000666(ATG12 antibody) at dilution of 1:500
  • Recommended dilutionWB : 1:200-1:2000
  • Product Description specificalUbiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
  • Gene nameATG12
  • Uniprot IDO94817
  • Observed M.W.48-50kd

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