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Alternative name
ATF6, ATF6 alpha, ATF6A antibody
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Catalog
A000664
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Rat
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Applications Tested/SuitableELISA,WB,IF,IHC,IP
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PurificationImmunogen affinity purified
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Immunogenactivating transcription factor 6
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IHCImmunohistochemistry of paraffin-embedded human cervical cancer tissue slide using A000664( ATF6 Antibody) at dilution of 1:50
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Western BlotMCF-7 cells were subjected to SDS PAGE followed by western blot with A000664( ATF6 Antibody) at dilution of 1:3000
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Recommended dilutionWB : 1:1000-1:10000
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Product Description specificalTransmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'- ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
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Gene nameATF6
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Uniprot IDP18850
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Observed M.W.90 kDa
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