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Alternative name
RAD30B antibody
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Catalog
A006612
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IP
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PurificationImmunogen affinity purified
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Immunogenpolymerase (DNA directed) iota
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A006612(POLI antibody) at dilution of 1:100
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Western Blotmouse testis tissue were subjected to SDS PAGE followed by western blot with A006612(POLI antibody) at dilution of 1:800
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalError-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
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Gene namePOLI
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Uniprot IDQ9UNA4
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Observed M.W.87 kDa
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