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Alternative name
OIP3, PK2, PK3, PKM2 antibody
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Catalog
A006492
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,IHC,WB
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PurificationImmunogen affinity purified
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ImmunogenPKM2 pyruvate kinase, muscle
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IHCImmunohistochemistry of paraffin-embedded human colon cancer using A006492(PKM antibody) at dilution of 1:50
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Western BlotWB result of 10078-2-AP (PKM antibody) with various lysates.
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalGlycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
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Gene namePKM2
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Uniprot IDP14618
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Observed M.W.58 kDa
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