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Alternative name
PDHK1 antibody
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Catalog
A006275
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,IHC,WB,IP
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PurificationImmunogen affinity purified
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Immunogenpyruvate dehydrogenase kinase, isozyme 1
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IHCImmunohistochemistry of paraffin-embedded human liver using A006275(PDK1 antibody) at dilution of 1:50
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Western Blotmouse liver tissue were subjected to SDS PAGE followed by western blot with A006275( PDK1 Antibody) at dilution of 1:2000
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Recommended dilutionWB : 1:500-1:4000
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Product Description specificalKinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
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Gene namePDK1
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Uniprot IDQ15118
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Observed M.W.50 kDa
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