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Alternative name
PAR3, PAR3A antibody
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Catalog
A006146
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,FC,IP
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PurificationImmunogen affinity purified
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Immunogenpar-3 partitioning defective 3 homolog (C. elegans)
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IHCImmunohistochemistry of paraffin-embedded human colon cancer using A006146(PARD3 antibody) at dilution of 1:50
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Western BlotMCF7 cells were subjected to SDS PAGE followed by western blot with A006146(PARD3 antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalAdapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.
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Gene namePARD3
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Uniprot IDQ8TEW0
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Observed M.W.180, 140-150, 100 kDa
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