StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat
PurificationImmunogen affinity purified
Immunogenp21 protein (Cdc42/Rac)-activated kinase 6
IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A006124(PAK6 antibody) at dilution of 1:100
Western BlotPC-3 cells were subjected to SDS PAGE followed by western blot with A006124(PAK6 antibody) at dilution of 1:400
Recommended dilutionWB : 1:500-1:5000
Product Description specificalSerine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.