StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat
PurificationImmunogen affinity purified
Immunogenopiate receptor-like 1
IHCImmunohistochemistry of paraffin-embedded human gliomas using A005997(OPRL1 antibody) at dilution of 1:100
Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A005997(OPRL1 antibody) at dilution of 1:500
Recommended dilutionWB : 1:500-1:5000
Product Description specificalG-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.