anti-NHLRC1 antibody

Contact Us
  • Alternative name

    EPM2B antibody

  • Catalog
    A005726
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,WB,IHC
  • PurificationImmunogen affinity purified
  • ImmunogenNHL repeat containing 1
  • IHCImmunohistochemistry of paraffin-embedded human heart using A005726(NHLRC1 antibody) at dilution of 1:50
  • Western BlotL02 cells were subjected to SDS PAGE followed by western blot with A005726(NHLRC1 antibody) at dilution of 1:400
  • Recommended dilutionWB : 1:200-1:2000
  • Product Description specificalE3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
  • Gene nameNHLRC1
  • Uniprot IDQ6VVB1
  • Observed M.W.45-47kd


Related products with anti-NHLRC1 antibody

Inquiry About anti-NHLRC1 antibody If you hope to order it or contact us directly, please contact us via sales@biobool.com. We will get back to you in 12hrs,Thanks!