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Alternative name
EPHEXIN, Ephexin 1, NGEF antibody
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Catalog
A005720
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IP
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PurificationImmunogen affinity purified
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Immunogenneuronal guanine nucleotide exchange factor
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalActs as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
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Gene nameNGEF
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Uniprot IDQ8N5V2
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Observed M.W.75 kDa
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