IHCImmunohistochemistry of paraffin-embedded human brain tissue slide using A000562( ARHGEF4 Antibody) at dilution of 1:50
Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A000562( ARHGEF4 Antibody) at dilution of 1:1000
Recommended dilutionWB : 1:500-1:5000
Product Description specificalActs as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.