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Alternative name
KIAA0521 antibody
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Catalog
A000561
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenrho/rac guanine nucleotide exchange factor (GEF) 18
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A000561(ARHGEF18 antibody) at dilution of 1:50
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Western Blotmouse testis tissue were subjected to SDS PAGE followed by western blot with A000561(ARHGEF18 antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalActs as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).
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Gene nameARHGEF18
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Uniprot IDQ6ZSZ5
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Observed M.W.120-130 kDa
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