StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
PurificationImmunogen affinity purified
Immunogennuclear receptor coactivator 3
IHCImmunohistochemistry of paraffin-embedded human lung cancer tissue slide using A005589( NCOA3 Antibody) at dilution of 1:50
Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A005589(NCOA3 antibody) at dilution of 1:300
Recommended dilutionWB : 1:200-1:2000
Product Description specificalNuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.