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Alternative name
ARHGEF1, GEF1, LBCL2, LSC, P115 RHOGEF, p115RhoGEF, SUB1.5 antibody
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Catalog
A000558
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,IHC,WB,IP
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PurificationImmunogen affinity purified
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ImmunogenRho guanine nucleotide exchange factor (GEF) 1
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IHCImmunohistochemistry of paraffin-embedded human colon using A000558(ARHGEF1 antibody) at dilution of 1:50
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Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A000558(ARHGEF1 antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:1000-1:5000
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Product Description specificalSeems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation.
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Gene nameARHGEF1
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Uniprot IDQ92888
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Observed M.W.102-110 kDa
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