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Alternative name
BZF1, IDOL antibody
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Catalog
A005492
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenmyosin regulatory light chain interacting protein
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IHCImmunohistochemistry of paraffin-embedded human testis using A005492(MYLIP antibody) at dilution of 1:50
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Western Blothuman cerebellum tissue were subjected to SDS PAGE followed by western blot with A005492(MYLIP antibody) at dilution of 1:400
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalE3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
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Gene nameMYLIP
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Uniprot IDQ8WY64
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Observed M.W.50kd
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