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Alternative name
PUM antibody
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Catalog
A005427
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,FC,IHC,IP
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PurificationImmunogen affinity purified
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Immunogenmucin 1, cell surface associated
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IHCImmunohistochemistry of paraffin-embedded human lung cancer using A005427(CA15-3,MUC1 antibody) at dilution of 1:50
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Western BlotA431 cells were subjected to SDS PAGE followed by western blot with A005427(CA15-3,MUC1 antibody) at dilution of 1:1500
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Product Description specificalThe alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack._x000D_The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein- protein interactions. Modulates signaling in ERK, SRC and NF- kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
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Uniprot IDP15941
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