anti-MTF2 antibody

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  • Alternative name

    PCL2 antibody

  • Catalog
    A005397
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC,IF,IP
  • PurificationImmunogen affinity purified
  • Immunogenmetal response element binding transcription factor 2
  • IHCImmunohistochemistry of paraffin-embedded human brain using A005397(MTF2 antibody) at dilution of 1:50
  • Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A005397(MTF2 antibody) at dilution of 1:600
  • Recommended dilutionWB : 1:200-1:2000
  • Product Description specificalPolycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
  • Gene nameMTF2
  • Uniprot IDQ9Y483
  • Observed M.W.45-46 kDa,55 kDa,60-61 kDa


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