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Alternative name
FLJ14471, GPCR, LGR6, VTS20631 antibody
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Catalog
A004766
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,WB,FC
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PurificationImmunogen affinity purified
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Immunogenleucine-rich repeat-containing G protein-coupled receptor 6
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IHCImmunohistochemistry of paraffin-embedded human testis using A004766(LGR6 antibody) at dilution of 1:50
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Western Blotmouse testis tissue were subjected to SDS PAGE followed by western blot with A004766(LGR6 antibody) at dilution of 1:100
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalReceptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
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Gene nameLGR6
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Uniprot IDQ9HBX8
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Observed M.W.104 kDa
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