Product Categories
-
Alternative name
kelch like 22 (Drosophila), Kelch like protein 22, KELCHL, KLHL22 antibody
-
Catalog
A004620
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman, Mouse ,Rat
-
Applications Tested/SuitableELISA,WB
-
PurificationImmunogen affinity purified
-
Immunogenkelch-like 22 (Drosophila)
-
Recommended dilutionWB : 1:500-1:5000
-
Product Description specificalSubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
-
Gene nameKLHL22
-
Uniprot IDQ53GT1
-
Observed M.W.72 kDa
-