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Alternative name
AMICA1 antibody
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Catalog
A004436
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC,IF,FC
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PurificationImmunogen affinity purified
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Immunogenadhesion molecule, interacts with CXADR antigen 1
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IHCImmunohistochemistry of paraffin-embedded human spleen using A004436(AMICA1 antibody) at dilution of 1:100
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Western BlotHL-60 cells were subjected to SDS PAGE followed by western blot with A004436(AMICA1 antibody) at dilution of 1:800
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalTransmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
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Gene nameAMICA1
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Uniprot IDQ86YT9
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Observed M.W.30kd,44kd,50-60kd
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