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Alternative name
KIAA0174 antibody
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Catalog
A004408
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IF,IHC,IP
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PurificationImmunogen affinity purified
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ImmunogenKIAA0174
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IHCImmunohistochemistry of paraffin-embedded human lung cancer using A004408(hIST1 antibody) at dilution of 1:200
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Western Blothuman skeletal muscle tissue were subjected to SDS PAGE followed by western blot with A004408(hIST1 antibody) at dilution of 1:300
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
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Gene nameKIAA0174
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Uniprot IDP53990
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Observed M.W.40 kDa
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