anti-IST1 antibody

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  • Alternative name

    KIAA0174 antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,WB,IF,IHC,IP
  • PurificationImmunogen affinity purified
  • ImmunogenKIAA0174
  • IHCImmunohistochemistry of paraffin-embedded human lung cancer using A004408(hIST1 antibody) at dilution of 1:200
  • Western Blothuman skeletal muscle tissue were subjected to SDS PAGE followed by western blot with A004408(hIST1 antibody) at dilution of 1:300
  • Recommended dilutionWB : 1:500-1:5000
  • Product Description specificalESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).
  • Gene nameKIAA0174
  • Uniprot IDP53990
  • Observed M.W.40 kDa

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