anti-IRF3 antibody

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  • Alternative name

    interferon regulatory factor 3, IRF 3, IRF3 antibody

  • Catalog
    A004389
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman, Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC,IF,IP,FC
  • PurificationImmunogen affinity purified
  • Immunogeninterferon regulatory factor 3
  • IHCImmunohistochemistry of paraffin-embedded human spleen using A004389(IRF3 antibody) at dilution of 1:50
  • Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A004389(IRF3 antibody) at dilution of 1:1000
  • Recommended dilutionWB : 1:500-1:5000
  • Product Description specificalKey transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
  • Gene nameIRF3
  • Uniprot IDQ14653
  • Observed M.W.49-55 kDa




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