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Alternative name
INV, NPHP2 antibody
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Catalog
A004369
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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Immunogeninversin
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IHCImmunohistochemistry of paraffin-embedded human breast cancer using A004369(INVS antibody) at dilution of 1:100
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Western BlotMCF7 cells were subjected to SDS PAGE followed by western blot with A004369(INVS antibody) at dilution of 1:100
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalRequired for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
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Gene nameINVS
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Uniprot IDQ9Y283
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Observed M.W.110-115 kDa
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