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Alternative name
INSIG 2, INSIG2, insulin induced gene 2, Insulin induced gene 2 protein antibody
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Catalog
A004334
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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Immunogeninsulin induced gene 2
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IHCImmunohistochemistry of paraffin-embedded human liver tissue slide using A004334( INSIG2 Antibody) at dilution of 1:50
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Western Blotrat liver tissue were subjected to SDS PAGE followed by western blot with A004334( INSIG2 Antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalMediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.
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Gene nameINSIG2
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Uniprot IDQ9Y5U4
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Observed M.W.30 kDa
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