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Alternative name
C9orf26, IL1F11, NFHEV antibody
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Catalog
A004271
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,IHC,WB
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PurificationImmunogen affinity purified
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Immunogeninterleukin 33
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IHCImmunohistochemistry of paraffin-embedded human tonsillitis tissue slide using A004271( IL33 Antibody) at dilution of 1:50
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Western BlotTransfected HEK-293 cells were subjected to SDS PAGE followed by western blot with A004271( IL33 Antibody) at dilution of 1:700
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalCytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). _x000D_In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin- associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).
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Gene nameIL33
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Uniprot IDO95760
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