StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat
PurificationImmunogen affinity purified
Immunogenintraflagellar transport 57 homolog (Chlamydomonas)
IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A004160(IFT57 antibody) at dilution of 1:50
Western Blotmouse retina tissue were subjected to SDS PAGE followed by western blot with A004160(IFT57 antibody) at dilution of 1:1000
Recommended dilutionWB : 1:200-1:2000
Product Description specificalRequired for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.