anti-IFIT2 antibody

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  • Alternative name

    CIG-42, G10P2, IFI54, ISG54 antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman, Mouse
  • Applications Tested/SuitableELISA,WB,IHC,IF
  • PurificationImmunogen affinity purified
  • Immunogeninterferon-induced protein with tetratricopeptide repeats 2
  • IHCImmunohistochemistry of paraffin-embedded human kidney tissue slide using A004137( IFIT2 Antibody) at dilution of 1:50
  • Western BlotA431 cells were subjected to SDS PAGE followed by western blot with A004137( IFIT2 Antibody) at dilution of 1:300
  • Recommended dilutionWB : 1:200-1:1000
  • Product Description specificalIFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
  • Gene nameIFIT2
  • Uniprot IDP09913
  • Observed M.W.50-55 kDa

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