StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman, Mouse
PurificationImmunogen affinity purified
Immunogeninterferon-induced protein with tetratricopeptide repeats 2
IHCImmunohistochemistry of paraffin-embedded human kidney tissue slide using A004137( IFIT2 Antibody) at dilution of 1:50
Western BlotA431 cells were subjected to SDS PAGE followed by western blot with A004137( IFIT2 Antibody) at dilution of 1:300
Recommended dilutionWB : 1:200-1:1000
Product Description specificalIFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.