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Alternative name
CIG-42, G10P2, IFI54, ISG54 antibody
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Catalog
A004137
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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Immunogeninterferon-induced protein with tetratricopeptide repeats 2
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IHCImmunohistochemistry of paraffin-embedded human kidney tissue slide using A004137( IFIT2 Antibody) at dilution of 1:50
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Western BlotA431 cells were subjected to SDS PAGE followed by western blot with A004137( IFIT2 Antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalIFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
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Gene nameIFIT2
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Uniprot IDP09913
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Observed M.W.50-55 kDa
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