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Alternative name
AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, FLJ92595, FLJ97926, Serpin A8, SERPINA8 antibody
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Catalog
A000393
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC,FC
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PurificationImmunogen affinity purified
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Immunogenangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
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IHCImmunohistochemistry of paraffin-embedded human liver slide using A000393( AGT Antibody) at dilution of 1:50
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Western BlotHepG2 cells were subjected to SDS PAGE followed by western blot with A000393(AGT antibody) at dilution of 1:600
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Recommended dilutionWB :1:200-1:2000;IHC:1:20-1:200
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Product Description specificalAngiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
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Gene nameAGT
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locationSecreted
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Uniprot IDP01019
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Calculated M.W.53kDa
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Observed M.W.52 kDa
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