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Alternative name
Amphiphysin,AMPH1,AMPH antibody
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Catalog
A000373
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IP
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PurificationImmunogen affinity purified
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Immunogenamphiphysin
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A000373(AMPH antibody) at dilution of 1:100
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Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A000373(AMPH antibody) at dilution of 1:1500
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Recommended dilutionWB :1:500-1:5000;IHC:1:20-1:200;IP:1:500-1:5000
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Product Description specificalAmphiphysin (AMPH), a synaptic vesicle-associated protein that is highly concentrated in nerve terminal, is an autoantigen of Stiff-Man syndrome with breast cancer. Amphiphysin contains a N-terminal BAR (Bin1/Amphiphysin/Rv167) domain followed by an endocytosis domain, and a C-terminal SH3 domain. Amphiphysin has been proposed to function as a linker between the clathrin coat and dynamin in the endocytosis of synaptic vesicles. It may also participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. (PMID: 8552632; 8245793; 10559861)
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Gene nameAMPH
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locationCell junction,Cytoplasm,Cytoplasmic vesicle,Cytoskeleton,Membrane,Synapse
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Uniprot IDP49418
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Calculated M.W.76kDa,observed 120kDa
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Observed M.W.115-125 kDa
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